GMO hazards with citations to journals


http://www.gmwatch.org/files/GMsoy_SustainableResponsible_Sept2010_Summa... Includes almost 160 citations... covers health and environmental evidence of harm 2010Citations in this report related to animal studies from GMWatch. They have not been read by SPI staff:50: Séralini, G.-E., Cellier, D., de Vendomois, J.S. 2007. New analysis of a rat feeding study with agenetically modified maize reveals signs of hepatorenal toxicity. Arch. Environ Contam Toxicol. 52,596–602.51: Kilic, A., Akay, M.T. 2008. A three generation study with genetically modified Bt corn in rats:Biochemical and histopathological investigation. Food and Chemical Toxicology 46, 1164–1170.52: Finamore, A., Roselli, M., Britti, S., Monastra, G., Ambra, R., Turrini, A., Mengheri, E. 2008.Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice.J. Agric. Food Chem. 56, 11533–11539.53: Velimirov, A., Binter, C., Zentek, J. 2008. Biological effects of transgenic maize NK603xMON810fed in long term reproduction studies in mice. Bundesministerium für Gesundheit, Familie undJugend Report, Forschungsberichte der Sektion IV Band 3/2008, Austria.-------------------------ABSTRACT HERE OF:A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize dietJudy A. Carman1,2*, Howard R. Vlieger3, Larry J. Ver Steeg4, Verlyn E.Sneller3, Garth W. Robinson5**, Catherine A. Clinch-Jones1, Julie I.Haynes6, John W. Edwards21 Institute of Health and Environmental Research, Kensington Park, SA, Australia.2 Health and the Environment, School of the Environment, Flinders University, BedfordPark, SA, Australia.3 Verity Farms, Maurice, Iowa, USA.4 Ana-Tech, Monroe, Wisconsin, USA.5 Sioux Center Veterinary Clinic, Sioux Center, Iowa, USA.6 School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia.* Email: judycarman@ozemail.com.au, judy.carman@flinders.edu.au.** Present: Robinson Veterinary Services PC, Sioux Centre, Iowa, USA.AbstractA significant number of genetically modified (GM) crops have been approved to enterhuman food and animal feed since 1996, including crops containing several GM genes'stacked' into the one plant. We randomised and fed isowean pigs (N=168) either a mixedGM soy and GM corn (maize) diet (N=84) or an equivalent non-GM diet (N=84) in a longtermtoxicology study of 22.7 weeks (the normal lifespan of a commercial pig fromweaning to slaughter). Equal numbers of male and female pigs were present in eachgroup. The GM corn contained double and triple-stacked varieties. Feed intake, weightgain, mortality and blood biochemistry were measured. Organ weights and pathologywere determined post-mortem. There were no differences between pigs fed the GM andnon-GM diets for feed intake, weight gain, mortality, and routine blood biochemistrymeasurements. The GM diet was associated with gastric and uterine differences in pigs.GM-fed pigs had uteri that were 25% heavier than non-GM fed pigs (p=0.025). GM-fedpigs had a higher rate of severe stomach inflammation with a rate of 32% of GM-fed pigscompared to 12% of non-GM-fed pigs (p=0.004). The severe stomach inflammation wasworse in GM-fed males compared to non-GM fed males by a factor of 4.0 (p=0.041), andGM-fed females compared to non-GM fed females by a factor of 2.2 (p=0.034).-----------------------------------------------ABSTRACT HERE FOR\Genetically modified crops safety assessments: present limits and possible improvements, Gilles-Eric Séralini1*, Robin Mesnage1, Emilie Clair1, Steeve Gress1, Joël Spiroux de Vendômois2 and Dominique Cellier3 * Corresponding author: Gilles-Eric Séralini criigen@unicaen.frAuthor Affiliations1 Laboratory of Biochemistry - IBFA, University of Caen, Esplanade de la Paix, 14032 Caen, Cedex, France 2 CRIIGEN, Paris, France 3 University of Rouen LITIS EA 4108, 76821 Mont-Saint-Aignan, FranceFor all author emails, please log on. Environmental Sciences Europe 2011, 23:10 doi:10.1186/2190-4715-23-10The electronic version of this article is the complete one and can be found online at: http://www.enveurope.com/content/23/1/10 Received: 17 January 2011Accepted: 1 March 2011Published: 1 March 2011 © 2011 Séralini et al; licensee Springer.AbstractPurposeWe reviewed 19 studies of mammals fed with commercialized genetically modified soybean and maize which represent, per trait and plant, more than 80% of all environmental genetically modified organisms (GMOs) cultivated on a large scale, after they were modified to tolerate or produce a pesticide. We have also obtained the raw data of 90-day-long rat tests following court actions or official requests. The data obtained include biochemical blood and urine parameters of mammals eating GMOs with numerous organ weights and histopathology findings.MethodsWe have thoroughly reviewed these tests from a statistical and a biological point of view. Some of these tests used controversial protocols which are discussed and statistically significant results that were considered as not being biologically meaningful by regulatory authorities, thus raising the question of their interpretations.ResultsSeveral convergent data appear to indicate liver and kidney problems as end points of GMO diet effects in the above-mentioned experiments. This was confirmed by our meta-analysis of all the in vivo studies published, which revealed that the kidneys were particularly affected, concentrating 43.5% of all disrupted parameters in males, whereas the liver was more specifically disrupted in females (30.8% of all disrupted parameters).ConclusionsThe 90-day-long tests are insufficient to evaluate chronic toxicity, and the signs highlighted in the kidneys and livers could be the onset of chronic diseases. However, no minimal length for the tests is yet obligatory for any of the GMOs cultivated on a large scale, and this is socially unacceptable in terms of consumer health protection. We are suggesting that the studies should be improved and prolonged, as well as being made compulsory, and that the sexual hormones should be assessed too, and moreover, reproductive and multigenerational studies ought to be conducted too.SOURCES INCLUDED IN THE QUOTES ABOVE

#crops #environment #health